Publikationen
Veröffentlichungen A - Z
Prof. Dr. rer. nat. Nico Scheer
Kapitel in einem Sammelwerk
Genetically Humanized Animal Models
Samuelsson, K. ; Scheer, Nico ; Wilson, I. ; Wolf, C.R. ; Henderson, C.J. (2017)
Comprehensive Medicinal Chemistry III. 3rd Edition. Saint Louis : Elsevier 2017. Seite: 130 - 149
978-0-12-803201-5
Knockout and humanized animal models to study membrane transporters in drug development
Scheer, Nico ; Chu, Xiaoyan ; Salphati, Laurent ; Zamek-Gliszczynski, Maciej J. (2016)
Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development. Cambridge : Royal Society of Chemistry 2016. Seite: 298 - 332
978-1-78262-379-3
Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs
Wolf, C. Roland ; Kapelyukh, Yury ; Scheer, Nico ; Henderson, Colin J. (2015)
Cambridge : RSC Publ. 2015. Seite: 152 - 176
978-1-78262-778-4
The use of transgenic animals to study drug metabolism
Henderson, Colin J. ; Wolf, C. Roland ; Scheer, Nico (2009)
Handbook of Drug Metabolism. 2nd Edition. New York : Informa Healthcare 2009. Seite: 637 - 658
978-1-4200-7647-9
Zeitschriftenartikel
Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice
Kapelyukh, Yury ; Henderson, Colin James ; Scheer, Nico ; Rode, Anja ; Wolf, Charles Roland (2019)
Drug Metabolism and Disposition. . (2019), H. Early view. - 43 Seiten
An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials
Scheer, Nico ; Henderson, Colin James ; Kapelyukh, Yury ; Rode, Anja ; Mclaren, Aileen W. ; MacLeod, Alastair Kenneth ; Lin, De ; Wright, Jayne ; Stanley, Lesley ; Wolf, C. Roland (2019)
Drug Metabolism and Disposition. . (2019), H. Early view. - 69 Seiten
The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
Wilson, C. E. ; Dickie, A. P. ; Schreiter, K. ; Wehr, R. ; Wilson, E. M. ; Bial, J. ; Scheer, Nico ; Wilson, I. D. ; Riley, R. J. (2018)
Archives of Toxicology. Springer. 92 (2018), H. 6. Seite: 1953 - 1967
1432-0738
The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
Wilson, Ian D. ; Wilson, Claire E. ; Scheer, Nico ; Dickie, A.P. ; Schreiter, K. ; Wilson, E. M. ; Riley, R. J. ; Wehr, R. ; Bial, J. (2017)
Biochemical pharmacology. Amsterdam : Elsevier. Volume 135 (2017). Seite: 139 - 150
1873-2968
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4–Humanized Mouse Studies With PBPK Modeling
Zhang, Jin ; Heimbach, Tycho ; Scheer, Nico ; Barve, Avantika ; Li, Wenkui ; Lin, Wen ; He, Handan (2016)
Journal of Pharmaceutical Sciences. Amsterdam : Elsevier. Volume 105 (2016), H. Issue 4. Seite: 1398 - 1404
0022-3549
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model
Dallas, Shannon ; Salphati, Laurent ; Gomez-Zepeda, David ; Wanek, Thomas ; Chen, Liangfu ; Chu, Xiaoyan ; Kunta, Jeevan ; Mezler, Mario ; Menet, Marie-Claude ; Chasseigneaux, Stephanie ; Declèves, Xavier ; Langer, Oliver ; Pierre, Esaie ; DiLoreto, Karen ; Hoft, Carolin ; Laplanche, Loic ; Pang, Jodie ; Pereira, Tony ; Andonian, Clara ; Simic, Damir ; Rode, Anja ; Yabut, Jocelyn ; Zhang, Xiaolin ; Scheer, Nico (2016)
Molecular Pharmacology. Bethesda, Md. : ASPET. 89 (2016), H. 5. Seite: 492 - 504
1521-0111
A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
Scheer, Nico ; Wilson, Ian D. (2016)
Drug Discovery Today. Amsterdam : Elsevier. 21 (2016), H. 2. Seite: 250 - 263
1359-6446
Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model
Scheer, Nico ; Kapelyukh, Yury ; Rode, Anja ; Oswald, Stefan ; Busch, Diana ; Mclaughlin, Lesley A. ; Lin, De ; Henderson, Colin J. ; Wolf, C. Roland (2015)
Drug Metabolism and Disposition. Bethesda : ASPET. 43 (2015), H. 11. Seite: 1679 - 1690
1521-009x
Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms
Hough, Lindsay B. ; Nalwalk, Julia W. ; Ding, Xinxin ; Scheer, Nico (2015)
Drug Metabolism and Disposition. . 43 (2015), H. 9. Seite: 1326 - 1330
1521-009x
Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo s
Henderson, Colin J. ; Mclaughlin, Lesley A. ; Scheer, Nico ; Stanley, Lesley A. ; Wolf, C. Roland (2015)
Molecular Pharmacology. Bethesda : ASPET. 87 (2015), H. 4. Seite: 733 - 739
1521-0111
Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
Luisier, Raphaëlle ; Lempiäinen, Harri ; Scherbichler, Nina ; Braeuning, Albert ; Geissler, Miriam ; Dubost, Valerie ; Müller, Arne ; Scheer, Nico ; Chibout, Salah-Dine ; Hara, Hisanori ; Picard, Frank ; Theil, Diethilde ; Couttet, Philippe ; Vitobello, Antonio ; Grenet, Olivier ; Grasl-Kraupp, Bettina ; Ellinger-Ziegelbauer, Heidrung ; Thomson, John P. ; Meehan, Richard R. ; Elcombe, Clifford R. ; Henderson, Colin J. ; Wolf, C. Roland ; Schwarz, Michael ; Moulin, Pierre ; Terranova, Remi ; Moggs, Jonathan G. (2014)
Toxicological Sciences. Oxford : Oxford University Press. 139 (2014), H. 2. Seite: 501 - 511
1094-2025
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
Salpati, Laurent ; Chu, Xiaoyan ; Chen, Liangfu ; Prasad, Bhagwat ; Dallas, Shannon ; Evers, Raymond ; Mamaril-Fishman, Donna ; Geier, Ethan G. ; Kehler, Jonathan ; Kunta, Jeevan ; Mezler, Mario ; Laplanche, Loic ; Pang, Jodie ; Soars, Matthew G. ; Unadkat, Jashvant D. ; van Waterschoot, Robert A.B. ; Yabut, Jocelyn ; Schinkel, Alfred H. ; Scheer, Nico ; Rode, Anja (2014)
Drug Metabolism and Disposition. Bethesda, Md. : ASPET. 42 (2014), H. 8. Seite: 1301 - 1313
1521-009X
Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism
Scheer, Nico ; Mclaughlin, Lesley A. ; Rode, Anja ; MacLeod, Alastair Kenneth ; Henderson, Colin J. ; Wolf, Roland C. (2014)
Drug Metabolism and Disposition. Bethesda, Md. : ASPET. 42 (2014), H. 6. Seite: 1022 - 1030
1521-009X
Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications
Scheer, Nico ; Wolf, C. Roland (2014)
Xenobiotica. Abingdon : Taylor & Francis. 44 (2014), H. 2. Seite: 96 - 108
1366-5928
Generation and utility of genetically humanized mouse models
Scheer, Nico ; Snaith, Mike ; Wolf, C. Roland ; Seibler, Jost (2013)
Drug Discovery Today. Amsterdam : Elsevier. Vol 18 (2013), H. 23-24. Seite: 1200 - 1211
1359-6446
Xenobiotic receptor humanized mice and their utility
Scheer, Nico ; Wolf, C. Roland (2013)
Drug Metabolism Reviews. London : Taylor & Francis. (2013), H. 1. Seite: 110 - 121
1097-9883
Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
Scheer, Nico ; Balimane, Praveen ; Hayward, Michael D. ; Buechel, Sandra ; Kauselmann, Gunther ; Wolf, C. Roland (2012)
Drug Metabolism and Disposition. Bethesda, Md. : ASPET. 40 (2012), H. 11. Seite: 2212 - 2218
1521-0111
Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines
Scheer, Nico ; Kapelyukh, Yury ; Rode, Anja ; Buechel, Sandra ; Wolf, C. Roland (2012)
Molecular Pharmacology. Bethesda, Md. : ASPET. 82 (2012), H. 6. Seite: 1022 - 1029
1521-0111
Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion
Lempiäinen, Harri ; Couttet, Philippe ; Bolognani, Federico ; Müller, Arne ; Dubost, Valérie ; Luisier, Raphaëlle ; Rio-Espinola, Alberto del ; Vitry, Veronique ; Unterberger, Elif B. ; Thomson, John P. ; Treindl, Fridolin ; Metzger, Ute ; Wrzodek, Clemens ; Hahne, Florian ; Zollinger, Tulipan ; Brasa, Sarah ; Kalteis, Magdalena ; Marcellin, Magali ; Giudicelli, Fanny ; Braeuning, Albert ; Morawiec, Laurent ; Zamurovic, Natasa ; Längle, Ulrich ; Scheer, Nico ; Schübeler, Dirk ; Goodman, Jay ; Chibout, Salah-Dine ; Marlowe, Jennifer ; Theil, Dietlinde ; Heard, David J. ; Grenet, Olivier ; Zell, Andreas ; Templin, Markus F. ; Meehan, Richard R. ; Wolf, Roland C. ; Elcombe, Clifford R. ; Schwarz, Michael ; Moulin, Pierre ; Terranova, Rémi ; Moggs, Jonathan G. (2012)
Toxicological Sciences. Oxford : Oxford University Press. 131 (2012), H. 2. Seite: 375 - 386
1094-2025
Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
Scheer, Nico ; Kapelyukh, Yury ; McEwan, Jillian ; Beuger, Vincent ; Stanley, Lesley A. ; Rode, Anja ; Wolf, C. Roland (2012)
Molecular Pharmacology. Bethesda, Md. : ASPET. 81 (2012), H. 1. Seite: 63 - 72
1521-0111
Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
Hasegawa, Maki ; Kapelyukh, Yury ; Tahara, Harunobu ; Seibler, Jost ; Rode, Anja ; Krueger, Sylvia ; Lee, Dongtao N. ; Wolf, C. Roland ; Scheer, Nico (2011)
Molecular Pharmacology. Bethesda, Md. : ASPET. 80 (2011), H. 33. Seite: 518 - 528
1521-0111
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo
Ross, Jillian ; Plummer, Simon M. ; Rode, Anja ; Scheer, Nico ; Bower, Conrad C. ; Vogel, Ortwin ; Henderson, Colin J. ; Wolf, C. Roland ; Elcombe, Clifford R. (2010)
Toxicological Sciences. Oxford : Oxford University Press. 116 (2010), H. 2. Seite: 452 - 466
1096-0929
In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice
Scheer, Nico ; Ross, Jillian ; Kapelyukh, Yury ; Rode, Anja ; Wolf, C. Roland (2010)
Drug Metabolism and Disposition. Bethesda : ASPET. 38 (2010), H. 7. Seite: 1046 - 1053
1521-009X
Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man
Henderson, Colin J. ; Scheer, Nico ; Wolf, C. Roland (2009)
Expert Review of Clinical Pharmacology. London : Taylor & Francis. 2 (2009), H. 2. Seite: 105 - 109
1751-2441
Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
Stanley, Lesley A. ; Horsburgh, Brian C. ; Ross, Jillian ; Scheer, Nico ; Wolf, C. Roland (2009)
Drug Metabolism Reviews. London : Taylor & Francis. 41 (2009), H. 1. Seite: 27 - 65
1097-9883
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
Scheer, Nico ; Ross, Jillian ; Rode, Anja ; Zevnik, Branko ; Niehaves, Sandra ; Faust, Nicole ; Wolf, C. Roland (2008)
Journal of Clinical Investigation. . 118 (2008), H. 9. Seite: 3228 - 3239
1558-8238
Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity
Stanley, Lesley A. ; Horsburgh, Brian C. ; Ross, Jillian ; Scheer, Nico ; Wolf, C. Roland (2006)
Drug Metabolism Reviews. . 38 (2006), H. 3. Seite: 515 - 597
1097-9883
Asymmetric localization of Numb:EGFP in dividing neuroepithelial cells during neurulation in Danio rerio
Reugels, Alexander M. ; Boggetti, Barbara ; Scheer, Nico ; Campos-Ortega, José A. (2006)
Developmental Dynamics. . 235 (2006), H. 4. Seite: 934 - 948
1097-0177
her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling
Hans, Stefan ; Scheer, Nico ; Riedl, Iris ; Weizäcker, Elisabeth von ; Blader, Patrick ; Campos-Ortega, José A. (2004)
Development. . 131 (2004), H. 12. Seite: 2957 - 2969
1477-9129
A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish
Scheer, Nico ; Riedl, Iris ; Warren, J.T. ; Kuwada, John Y. ; Campos-Ortega, José A. (2002)
Mechanism of Development. . 112 (2002), H. 1-2. Seite: 9 - 14
0925-4773
Notch signaling is required for arterial-venous differentiation during embryonic vascular development
Lawson, Nathan D. ; Scheer, Nico ; Pham, Van N. ; Kim, Ceol-Hee ; Chitnis, Ajay B. ; Campos-Ortega, José A. ; Weinstein, Brant M. (2001)
Development. . 128 (2001), H. 19. Seite: 3675 - 3683
1477-9129
An instructive function for Notch in promoting gliogenesis in the zebrafish retina
Scheer, Nico ; Groth, Anne ; Hans, Stefan ; Campos-Ortega, José A. (2001)
Development. . 128 (2001), H. 7. Seite: 1099 - 1107
0950-1991
Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins
Halbach, Thorsten ; Scheer, Nico (2000)
Nucleic Acids Research. . 28 (2000), H. 18. Seite: 3542 - 3550
1362-4962
Use of the Gal4-UAS technique for targeted gene expression in the zebrafish
Scheer, Nico ; Campos-Ortega, José A. (1999)
Mechanism of Development. . 80 (1999), H. 2. Seite: 153 - 158
0925-4773
Konferenzschriften
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
Kazuki, Yasuhiro ; Kobayashi, Kaoru ; Hirabayashi, Masumi ; Abe, Satoshi ; Kajitani, Naoyo ; Kazuki, Kanoko ; Takehara, Shoko ; Takiguchi, Masato ; Satoh, Daisuke ; Kuze, Jiro ; Sakuma, Tetsushi ; Kaneko, Takehito ; Mashimo, Tomoji ; Osamura, Minori ; Hashimoto, Mari ; Wakatsuki, Riko ; Hirashima, Rika ; Fujiwara, Ryoichi ; Deguchi, Tsuneo ; Kurihara, Atsushi ; Tsukazaki, Yasuko ; Senda, Naoto ; Yamamoto, Takashi ; Scheer, Nico ; Oshimura, Mitsuo (2019)
PNAS Proceedings of the National Academy of Sciences of the United States of America. 2019. Seite: 3072 - 3081
Alle Veröffentlichungen von Professoren und Professorinnen sowie Mitarbeiterinnen und Mitarbeitern der FH Aachen auf einen Blick, übersichtlich nach Autorennamen sortiert.
Die Veröffentlichungslisten werden automatisiert von der Datenbank OPUS in Ihre FH-Homepage ("Menschenseite") exportiert.
Bitte melden Sie Ihre Veröffentlichungen an das OPUS-Team der Bibliothek opusbibliothek.fh-aachen.de